The relationship between diet, especially polyphenols, and health has been receiving increasing attention. Polyphenols were degraded by gut microbiota into metabolites and acted on the body to exert many bioactivities from several targets such as antioxidative stress, anti-inflammation, intestinal barrier and gut microbiota modulation. After long-term treatment of mice with anthocyanins from Lycium ruthenicum Murray (ACN), antioxidant status in liver (T-AOC, T-SOD, CAT, GSH and GSH-Px were increased and AST, ALT, ALP and MDA were decreased), anti-inflammatory status in colon (the expression of mRNA of iNos, Cox-2, Tnf-α, Il-6, Il-1β and Ifn-γ were significantly reduced), intestinal barrier (the expression of mRNA of Zo-1, Occludin, Claudin-1 and Muc1 were significantly increased) and gut microbiota (Barnesiella, Alistipes, Eisenbergiella, Coprobacter and Odoribacter were proliferated) were all regulated in ACN group. Meanwhile, the content of short-chain fatty acids in cecal contents and feces were increased. Taken together, long-term intake of ACN could promote organism healthy and these results have important implications for the development of ACN as a functional food ingredient.

饮食尤其是多酚与健康之间的关系日益受到关注。多酚被肠道菌群降解成代谢产物，并作用于人体，从而发挥多种靶标的多种生物活性，例如抗氧化应激，抗炎，肠屏障和肠道菌群调节。在用枸杞枸杞（ACN）的花色苷长期治疗小鼠后，肝脏中的抗氧化剂状态（T-AOC，T-SOD，CAT，GSH和GSH-Px升高，AST，ALT，ALP和MDA降低） ，结肠抗炎状态（iNos，Cox-2，Tnf-α，Il-6，Il-1β和Ifn-γ的mRNA表达ACN组的肠道屏障（Zo-1，Occludin，Claudin-1和Muc1的mRNA的表达均显着增加）和肠道菌群（Barnesiella，Alistipes，Eisenbergiella，Coprobacter和Odoribacter均增殖）均受到调节。 。同时，盲肠和粪便中短链脂肪酸的含量增加。综上所述，长期摄入ACN可以促进机体健康，这些结果对ACN作为功能性食品成分的发展具有重要意义。