We herein report a novel entry towards chiral α-SCF3-β2,2-amino acids by carrying out the ammonium salt-catalyzed α-trifluoromethylthiolation of isoxazolidin-5-ones. This approach allowed for high enantioselectivities and high yields and the obtained heterocycles proved to be versatile platforms to access other targets of potential interest.

中文翻译：

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α-芳基-α-SCF3-β2,2-氨基酸的对映选择性催化合成。

我们在此报告了通过进行异恶唑烷-5-酮的铵盐催化的α-三氟甲硫基化来获得手性α-SCF3-β2,2-氨基酸的新途径。这种方法具有高对映选择性和高产率，并且所获得的杂环被证明是访问其他潜在感兴趣的目标的通用平台。