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Pseudoguaianelactones A–C: three unusual sesquiterpenoids from Lindera glauca with anti-inflammatory activities by inhibiting the LPS-induced expression of iNOS and COX-2†
Chemical Communications ( IF 6.164 ) Pub Date : 2019-12-27 , DOI: 10.1039/c9cc09159a
Qing-feng Ruan; Shi-qin Jiang; Xiao-yun Zheng; Yu-qian Tang; Bao Yang; Tao Yi; Jing Jin; Hui Cui; Zhongxiang Zhao

The pseudoguaianelactones A (1) and B (2), two novel sesquiterpene lactones with an unprecedented [5,7,7] ring system featuring an α-methylene-γ-lactone moiety, together with a new pseudoguaianelactone C (3) were isolated from the roots of Lindera glauca. Pseudoguaianelactones A–C (1–3) inhibited nitric oxide (NO) production, with IC50 values ranging from 1.38 to 4.00 μM. Moreover, all compounds significantly suppressed the production of pro-inflammatory mediators (TNF-α, IL-6, IL-1β and PGE2) and the protein expression of the enzymes iNOS and COX-2.
更新日期:2020-01-15

 

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