Gallium(iii) complexes with polypridyl ligands are shown to kill bulk osteosarcoma cells and osteosarcoma stem cells (OSCs) with up to nanomolar potency. The most effective complex induces apoptosis in osteosarcoma cells by damaging genomic DNA. To the best of our knowledge this is the first investigation into metal-based anti-OSC agents.

中文翻译：

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镓（iii）-聚吡啶基复合物可作为抗骨肉瘤干细胞药物。

镓（iii）与聚pridyl配体的复合物显示可以杀死大量的骨肉瘤细胞和骨肉瘤干细胞（OSC），其效力高达纳摩尔浓度。最有效的复合物通过破坏基因组DNA诱导骨肉瘤细胞凋亡。据我们所知，这是对金属基抗OSC试剂的首次调查。