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Mixed Modification of the Surface Microstructure and Chemical State of Polyetheretherketone to Improve Its Antimicrobial Activity, Hydrophilicity, Cell Adhesion, and Bone Integration
ACS Biomaterials Science & Engineering ( IF 5.8 ) Pub Date : 2020-01-07 , DOI: 10.1021/acsbiomaterials.9b01148
Rui Ding 1 , Taijun Chen 1 , Qizhen Xu 1 , Ran Wei 1 , Bo Feng 1 , Jie Weng 1 , Ke Duan 1 , Jianxin Wang 1 , Kai Zhang 2 , Xingdong Zhang 1, 2
Affiliation  

Polyetheretherketone (PEEK) is becoming an attractive surgical implant material in the biomedical field. However, its hydrophobicity and biological inertia have seriously hindered its development in the field of biomaterials and application in clinic. In this work, a mixed modification approach of the surface structure and chemical state was proposed to improve hydrophilicity and bioactivity of PEEK and meanwhile endowed it with antimicrobial properties. First, the effect of mixed acids of nitric acid and concentrated sulfuric acid with different volume ratios on the surface morphology of PEEK was quantitatively investigated, so as to obtain an optimal mixed acid of nitric acid and concentrated sulfuric acid with a volume ratio that could create a multilevel porous structure. Based on this, chemical grafting of ethylenediamine was conducted to achieve amination on the surface of the PEEK. The results showed that such double modification of the surface structure and chemical state could endow PEEK not only with antimicrobial activity but also with good hydrophilicity, cell compatibility, and bioactivity, which were beneficial to improve the bone integration ability of PEEK greatly.

中文翻译:

聚醚醚酮的表面微观结构和化学状态的混合修饰,以提高其抗菌活性,亲水性,细胞粘附力和骨整合度

聚醚醚酮(PEEK)在生物医学领域正成为一种有吸引力的外科植入材料。然而,其疏水性和生物惯性严重阻碍了其在生物材料领域的发展和在临床上的应用。在这项工作中,提出了一种表面结构和化学状态的混合改性方法,以提高PEEK的亲水性和生物活性,同时赋予其抗菌性能。首先,定量研究了不同体积比的硝酸和浓硫酸的混合酸对PEEK表面形貌的影响,从而获得了一种最佳的硝酸和浓硫酸的混合比,可以形成聚醚醚酮。多级多孔结构。基于此,进行乙二胺的化学接枝以实现PEEK表面的胺化。结果表明,表面结构和化学状态的这种双重修饰不仅可以赋予PEEK抗菌活性,而且还具有良好的亲水性,细胞相容性和生物活性,有利于大大提高PEEK的骨整合能力。
更新日期:2020-01-07
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