Polarity is the basis for the generation of cell diversity, as well as the organization, morphogenesis, and functioning of tissues. Studies in Caenorhabditis elegans have provided much insight into PAR-protein mediated polarity; however, the molecules and mechanisms critical for cell polarization within the plane of epithelia have been identified in other systems. Tissue polarity in C. elegans is organized by Wnt-signaling with some resemblance to the Wnt/planar cell polarity (PCP) pathway, but lacking core PCP protein functions. Nonetheless, recent studies revealed that conserved PCP proteins regulate directed cell migratory events in C. elegans, such as convergent extension movements and neurite formation and guidance. Here, we discuss the latest insights and use of C. elegans as a PCP model.

中文翻译：

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组织极性和PCP蛋白功能：秀丽隐杆线虫是一种新兴模型。

极性是细胞多样性以及组织，形态发生和组织功能的基础。秀丽隐杆线虫的研究为PAR蛋白介导的极性提供了很多见识。然而，在其他系统中已经鉴定出对上皮平面内的细胞极化至关重要的分子和机制。秀丽隐杆线虫的组织极性是通过Wnt信号组织的，与Wnt /平面细胞极性（PCP）途径有些相似，但缺少核心PCP蛋白功能。但是，最近的研究表明，保守的PCP蛋白可调节秀丽隐杆线虫的定向细胞迁移事件，例如会聚的延伸运动，神经突的形成和引导。在这里，我们讨论线虫作为PCP模型的最新见解和用法。