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A Flexible Strategy for Modular Synthesis of Curcuminoid-BF2 /Curcuminoid Pairs and Their Comparative Antiproliferative Activity in Human Cancer Cell Lines.
ChemMedChem ( IF 3.4 ) Pub Date : 2019-12-24 , DOI: 10.1002/cmdc.201900640
Rodrigo Abonia 1, 2 , Kenneth K Laali 2 , Dawn Raja Somu 2 , Scott D Bunge 3 , Esther C Wang 3
Affiliation  

A facile protocol that enables synthetic interconversion of CUR-BF2 and CUR compounds is described that significantly widens the preparative scope of curcuminoids, providing access to larger libraries of compounds, thus enabling comparative antiproliferative and apoptotic study of a larger library of synthetic analogs in cancer cell lines.

中文翻译:

姜黄素-BF2 /姜黄素对的模块化合成及其在人癌细胞系中比较抗增殖活性的灵活策略。

描述了一种实现CUR-BF2和CUR化合物合成相互转化的简便协议,该协议显着拓宽了姜黄素的制备范围,提供了更大的化合物库,从而能够对癌细胞中更大的合成类似物库进行比较抗增殖和凋亡研究线。
更新日期:2020-01-22
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