4A zeolite has reasonable adsorption and frame support properties thanks to its special pore structure and large surface area. This paper aims at improving the properties of microspheres by introducing zeolite as structural modifier. Therefore, the 4A zeolite/sodium alginate (SA)/Chitosan (CS) thiamethoxam microspheres (4A/SA/CS MCs) were hereby prepared and optimized through Response Surface Methodology. The Box-Behnken design was used to build the model and to analyze the effects of the concentration of sodium alginate, calcium chloride and 4A zeolite on the response value-loading efficiency. Furthermore, the fabricated 4A/SA/CS MCs were characterized by fourier transform infrared spectroscopy, scanning electron microscope, X-ray diffraction, differential scanning calorimetry. The performances of 4A/SA/CS TMCs such as the swelling rate, particle size, slow-release behaviors were systematically investigated. The phytotoxicity and insect activity of 4A/SA/CS MCs were also evaluated. The experimental results illustrated that the relationship between the response value and three independent variables were corresponded with the quadratic model. The properties of microspheres indicated that microspheres containing 4A zeolite had better LE and EE, displayed good sustained-release property and thermal stability, possessed persistent insecticidal activity as well as high biosafety.

4A沸石具有特殊的孔结构和较大的表面积，因此具有合理的吸附和框架支撑性能。本文旨在通过引入沸石作为结构改性剂来改善微球的性能。因此，据此通过响应表面方法制备并优化了4A沸石/藻酸钠（SA）/壳聚糖（CS）噻虫嗪微球（4A / SA / CS MC）。使用Box-Behnken设计建立模型，并分析藻酸钠，氯化钙和4A沸石的浓度对响应值加载效率的影响。此外，通过傅立叶变换红外光谱，扫描电子显微镜，X射线衍射，差示扫描量热法对制得的4A / SA / CS MC进行了表征。4A / SA / CS TMC的性能，例如膨胀率，对粒径，缓释行为进行了系统的研究。还评估了4A / SA / CS MC的植物毒性和昆虫活性。实验结果表明，响应值与三个自变量之间的关系与二次模型相对应。微球的性质表明，含4A沸石的微球具有更好的性能。LE和EE具有良好的缓释性能和热稳定性，具有持久的杀虫活性以及很高的生物安全性。