BACKGROUND The nucleus accumbens (NAc) is a ventral striatal structure underlying reward, reinforcement, and motivation, with extensive anatomic and functional connections to a wide range of affective processing structures (medial prefrontal cortex (mPFC), amygdala, and insula). Characterizing how acute alcohol intake affects resting state functional connectivity (rsFC) between the nucleus accumbens (NAc) and these regions will improve mechanistic understanding of alcohol's neurobehavioral effects, including the neural overlap between acute alcohol effects and pain processing. METHODS Fifteen healthy social drinkers (10 women; age: 25-45 years) were included in the study. Participants completed one session in which they consumed an alcohol dose targeting a breath alcohol concentration of 0.08 g/dL, and in a second a placebo beverage. Nine-minute resting state fMRI scans were acquired 30-35 min after beverage administration during each session. rsFC between NAc and a priori corticolimbic regions of interest (mPFC, amgydala, and insula), were compared between beverage conditions. We also conducted an exploratory whole-brain seed-to-voxel analysis of NAc FC. RESULTS Alcohol intake reduced rsFC between NAc and mPFC, as well as NAc and amygdala. Alcohol also reduced rsFC between NAc and a 97-voxel cluster including bilateral paracingulate cortex and anterior cingulate cortex. CONCLUSIONS Findings suggest that acute alcohol intake reduces rsFC between NAc and several structures, including mPFC, amygdala, and rostral ACC in healthy social drinkers. These structures underlie reward, motivated behavior, and emotion regulation, and may provide mechanistic insight to how alcohol affects related processes, including pain.

中文翻译：

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急性饮酒会改变伏隔核与疼痛相关皮质皮质结构的静息状态功能连通性。

背景技术伏伏核（NAc）是一种奖励，增强和动机基础的腹侧纹状体结构，与广泛的情感加工结构（内侧前额叶皮层（mPFC），杏仁核和绝缘体）具有广泛的解剖学和功能性连接。表征急性酒精摄入如何影响伏伏核（NAc）与这些区域之间的静止状态功能连接（rsFC），将改善对酒精神经行为作用的机械理解，包括急性酒精作用与疼痛处理之间的神经交叠。方法研究纳入了15名健康的社会饮酒者（10名妇女；年龄：25-45岁）。参与者完成了一个疗程，在该疗程中他们消耗了以0.08 g / dL的呼吸酒精浓度为目标的酒精剂量，并在第二次服用了安慰剂饮料。每次给药后30-35分钟采集9分钟的静息状态fMRI扫描。在饮料条件之间，比较了NAc和感兴趣的先天性皮质寡糖区域（mPFC，amgydala和绝缘体）之间的rsFC。我们还对NAc FC进行了全脑种子到体素的探索性分析。结果酒精摄入降低了NAc和mPFC之间以及NAc和杏仁核之间的rsFC。酒精还降低了NAc和97体素簇之间的rsFC，该簇包括双侧有顶索的皮层和前有顶索的皮层。结论研究结果表明，在健康的社会饮酒者中，急性饮酒可降低NAc与包括mPFC，杏仁核和鼻侧ACC在内的几种结构之间的rsFC。这些结构是奖励，激励行为和情绪调节的基础，