OBJECTIVE To ascertain the association between vasomotor menopausal symptoms (VSM), hot flushes and night sweats, and cardiovascular disease, coronary heart disease and cerebrovascular disease. STUDY DESIGN The study sample comprised 8881 women (aged 45-50 years) with available hospital separation data from the 1946-51 cohort (1996-2016) of the ongoing Australian Longitudinal Study on Women's Health, a national prospective cohort study. MAIN OUTCOME MEASURES First fatal or non-fatal cardiovascular disease, coronary heart disease, and cerebrovascular disease events were obtained through linkage with hospital admission data, the National Death Index, and Medicare Benefits Schedule. Hot flushes and night sweats were assessed via questionnaires at each main survey. Additionally, we calculated the duration of symptoms based on whether or not women reported vasomotor menopausal symptoms in each survey. RESULTS There were 925 cardiovascular disease, 484 coronary heart disease and 154 cerebrovascular disease events. There was no consistent evidence of any association with vasomotor menopausal symptoms, hot flushes and night sweats. We did find marginally statistically significant associations between presence of night sweats and cardiovascular disease (Hazard Ratio = 1.18, 95 % Confidence Interval: 1.01-1.38), and between the duration of vasomotor menopausal symptoms [years] and coronary heart disease (Hazard Ratioper year = 1.03, 95 % Confidence Interval: 1.00-1.05). However, given the number of associations tested, these findings could very well have arisen by chance. CONCLUSION In this large longitudinal study with 20 years of follow-up and clinical outcomes we did not find a convincing association between vasomotor menopausal symptoms, hot flushes, night sweats and cardiovascular disease, coronary heart disease and cerebrovascular disease.

中文翻译：

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血管舒缩性更年期症状和中年心血管疾病风险：一项纵向研究

目的 确定血管舒缩性更年期症状 (VSM)、潮热和盗汗与心血管疾病、冠心病和脑血管疾病之间的关联。研究设计 该研究样本包括 8881 名女性（年龄 45-50 岁），他们拥有来自正在进行的澳大利亚妇女健康纵向研究（一项全国性前瞻性队列研究）的 1946-51 年队列（1996-2016 年）的可用医院分离数据。主要结局指标通过与入院数据、国家死亡指数和医疗保险福利表相关联，获得首次致命或非致命心血管疾病、冠心病和脑血管疾病事件。在每次主要调查中通过问卷评估潮热和盗汗。此外，我们根据每次调查中女性是否报告血管舒缩症状来计算症状持续时间。结果心血管疾病925例，冠心病484例，脑血管疾病154例。没有一致的证据表明与血管舒缩性更年期症状、潮热和盗汗有任何关联。我们确实发现盗汗与心血管疾病（危险比 = 1.18，95% 置信区间：1.01-1.38）之间以及血管舒缩性更年期症状持续时间 [年] 与冠心病（危险比年）之间存在统计学上的显着关联= 1.03，95% 置信区间：1.00-1.05)。然而，考虑到测试的关联数量，这些发现很可能是偶然出现的。