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Manipulating and studying triglyceride droplets in microfluidic devices.
Biochimie ( IF 3.9 ) Pub Date : 2019-12-24 , DOI: 10.1016/j.biochi.2019.12.010
Sébastien Marze 1 , Hoang Thanh Nguyen 2 , Mélanie Marquis 3
Affiliation  

Triglyceride is the main lipid class in nature, found as droplets in both living systems and man-made products (such as manufactured foods and drugs). Characterizing triglyceride droplets in situ in these systems is complex due to many environmental interactions. To answer basic research questions about droplet formation, structuration, stability, or degradation, microfluidic strategies were developed, allowing well-controlled droplets to be formed, manipulated, and studied. In this review, these strategies are described, starting with the presentation of droplet production devices, with applications essentially related to microencapsulation and delivery, then detailing methods to monitor droplet degradation in situ and in real time, finishing with microfluidic platforms allowing the investigation of many aspects of biological lipid droplets simultaneously.

中文翻译:

在微流控设备中操纵和研究甘油三酸酯液滴。

甘油三酸酯是自然界中的主要脂质类别,在生命系统和人造产品(例如人造食品和药品)中均以液滴形式存在。由于许多环境相互作用,在这些系统中原位表征甘油三酸酯滴是复杂的。为了回答有关液滴形成,结构化,稳定性或降解的基础研究问题,开发了微流控策略,可以控制,控制和控制液滴的形成,研究和研究。在本篇综述中,将介绍这些策略,首先介绍液滴生产设备,然后介绍与微囊化和递送基本相关的应用,然后详细介绍用于就地和实时监测液滴降解的方法,
更新日期:2019-12-25
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