AIMS We investigated the 2-year clinical outcomes of patients with acute myocardial infarction (AMI) and prediabetes after new-generation drug-eluting stents implantation. METHODS A total of 11,962 patients with AMI were classified into normoglycemia (group A; 3,080), prediabetes (group B; 3,709), and diabetes (group C; 5,173) groups. The primary outcomes were the patient-oriented composite outcomes (POCOs) defined as all-cause death, recurrent myocardial infarction (Re-MI), and any repeat revascularization. Secondary outcomes were the individual components of POCOs and stent thrombosis (ST). RESULTS POCOs in groups B and C were significantly higher than those in group A. Cardiac death (adjusted hazard ratio [aHR]: 1.957, 95% confidence interval [CI]: 1.126-3.402; p = 0.017) and any repeat revascularization (aHR: 1.597, 95% CI: 1.052-2.424; p = 0.028) rates were significantly higher in group B than in group A. Re-MI (aHR: 1.884, 95% CI: 1.201-2.954; p = 0.006) and death or MI (aHR: 1.438, 95% CI: 1.098-1.884; p = 0.008) were significantly higher in group C than in group B. CONCLUSIONS In this study, prediabetes showed bad clinical outcomes post AMI. However, larger randomized controlled studies including ethnically diverse population are needed to confirm these harmful cardiovascular effects of prediabetes in the future.

中文翻译：

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糖尿病前期对使用新一代药物洗脱支架进行PCI的急性心肌梗死患者长期临床结局的影响。

目的我们研究了新一代药物洗脱支架植入后急性心肌梗死（AMI）和糖尿病前期患者的两年临床结局。方法将11,962例AMI患者分为正常血糖（A组； 3,080组），糖尿病前期（B组； 3,709组）和糖尿病（C组； 5,173组​​）。主要结局是以患者为中心的综合结局（POCO），定义为全因死亡，复发性心肌梗塞（Re-MI）和任何重复的血运重建。次要结局为POCO和支架内血栓形成（ST）的各个组成部分。结果B组和C组的POCO显着高于A组。心脏死亡（经调整的危险比[aHR]：1.957，95％置信区间[CI]：1.126-3.402； p = 0.017）和任何重复的血运重建（aHR） ：1.597，95％CI：1.052-2.424；实测值：100。p = 0.028）B组的发生率显着高于A组.Re-MI（aHR：1.884，95％CI：1.201-2.954; p = 0.006）和死亡或MI（aHR：1.438，95％CI：1.098）结论在本研究中，前驱糖尿病显示出AMI后不良的临床结局。但是，需要更大范围的随机对照研究，包括不同种族的人群，以证实未来这些前驱糖尿病对心血管的有害影响。