The bioaccessibility of semivolatile organic compounds (SVOCs) via inhalation has rarely been studied, as indicated by the literature. There is no model to calculate the SVOC bioaccessibility following inhalation, and measurement data have focused on only a few polycyclic aromatic hydrocarbons (PAHs) in the particle phase. The present work developed a mechanistic model to address the mass transfer of inhaled SVOCs among the gas, particle and mucus phases in the human respiratory tract. The model considers (1) the SVOC partitioning between the gas and particle phases as well as between the gas and mucus phases and (2) the deposition of gas- and particle-phase SVOCs in the mucus of the respiratory tract. Based on the model, the inhalation bioaccessibility for 72 SVOCs was calculated. The SVOCs were measured in French dwellings at the nationwide scale, and their median concentrations in both the gas and particle phases were used for the bioaccessibility calculations. The results show that the inhalation bioaccessibility varies considerably from one compound to another, e.g., between 0.62 and 1.00 for phthalates, between 0.71 and 0.79 for polybrominated diphenyl ethers (PBDEs), between 0.48 and 0.56 for polychlorinated biphenyls (PCBs), between 0.48 and 1.00 for different chemical families of pesticides and between 0.48 and 0.90 for PAHs.

如文献所述，很少研究通过吸入对半挥发性有机化合物（SVOC）的生物可及性。尚无模型来计算吸入后SVOC的生物可及性，并且测量数据仅集中于颗粒相中的少数多环芳烃（PAH）。目前的工作开发了一种机械模型来解决人呼吸道中气相，颗粒和粘液相之间吸入的SVOC的质量转移。该模型考虑了（1）气相和颗粒相之间以及气相和粘液相之间的SVOC分配，以及（2）气相和颗粒相SVOC在呼吸道粘液中的沉积。根据该模型，计算了72种SVOC的吸入生物可及性。在全国范围内在法国住宅中测量了SVOC，并将气相和颗粒相中的中值浓度用于生物可及性计算。结果表明，一种化合物之间的吸入生物可及性差异很大，例如邻苯二甲酸酯在0.62至1.00之间，多溴联苯醚（PBDEs）在0.71至0.79之间，多氯联苯（PCBs）在0.48至0.56之间，在0.48至0.56之间。农药的不同化学族为1.00，多环芳烃为0.48至0.90。