A multifunctional photo-thermal therapeutic nano-platform Y2O3: Nd3+/Yb3+/Er3+@SiO2@Cu2S (YR-Si-Cu2S) was designed through a core–shell structure, expressing the function of bio-tissue imaging, real-time temperature detection, and photo-thermal therapy under 808 nm light excitation. In this system, the core Y2O3: Nd3+/Yb3+/Er3+ (YR) takes the responsibility of emitting optical information and monitoring temperature, while the shell Cu2S nano-particles carry most of the photo-thermal conversion function. The temperature sensing characteristic was achieved by the fluorescence intensity ratio using the thermally coupled energy levels (TCLs) S3/24/H211/2 of Er3+, and its higher accuracy for real-time temperature measurement in the bio-tissue than that of an infrared thermal camera was also proved by sub-tissue experiments. Furthermore, the photo-thermal effect of the present nano-system Y2O3: Nd3+/Yb3+/Er3+@SiO2@Cu2S was confirmed by Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) ablation. Results indicate that YR-Si-Cu2S has application prospect in temperature-controlled photo-thermal treatment and imaging in bio-tissues.

中文翻译：

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808 nm激光触发自监测光热治疗纳米系统Y2O3：Nd3+/Yb3+/Er3+@SiO2@Cu2S

通过核壳结构设计了一种多功能光热治疗纳米平台Y2O3：Nd3+/Yb3+/Er3+@SiO2@Cu2S（YR-Si-Cu2S），表达了生物组织成像、实时温度检测的功能和 808 nm 光激发下的光热疗法。在该系统中，核心Y2O3：Nd3+/Yb3+/Er3+ (YR)负责发射光学信息和监测温度，而壳层Cu2S纳米颗粒承担大部分光热转换功能。温度传感特性是通过使用 Er3+ 的热耦合能级 (TCL) S3/24/H211/2 的荧光强度比来实现的，并且其在生物组织中的实时温度测量精度高于红外线热像仪也得到了亚组织实验的证实。此外，本纳米系统 Y2O3：Nd3+/Yb3+/Er3+@SiO2@Cu2S 的光热效应被大肠杆菌（E.coli）和金黄色葡萄球菌（S.aureus）消融证实。结果表明，YR-Si-Cu2S在温控光热处理和生物组织成像方面具有应用前景。