Abstract In the last decade, the use of alanine/Electronic Paramagnetic Resonance (EPR) system was extended to radiotherapy doses. In stereotactic radiosurgery, doses up to 70 Gy are delivered to the brain tumor preserving healthy tissues. This type of treatment is delivered using dedicated equipment, like Cyberknife or Gamma Knife. Alanine dosimeters are characterized by their small size (5 mm diameter) and by similarity with tissue. They are well adapted for this wide dose range for which the dosimeter response is linear, independent of dose rate and energy for the range around few MeV. Therefore Alanine/EPR system is a suitable method for accurate and stable dose measurements as passive dosimeters for narrow treatment beams, which makes it an excellent candidate for end to end testing of radiosurgery treatments using Gamma Knife. The present work describes the development of the alanine/EPR method at Horia Hulubei National Institute for Physics and Nuclear Engeneering (IFIN-HH) in Romania including the optimization of system parameters for the radiosurgery dose range in the frame of an IFIN-HH and the French national metrology institute Laboratoire National Henri Becquerel federated by the Laboratoire National de metrologie et d’Essais (LNE-LNHB) collaboration. Romanian alanine dose measurements capability is presented regarding a comparison of calibration curves between both National Laboratories using Bruker and Synergy Health alanine pellets.

中文翻译：

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在罗马尼亚伽玛刀系统的质量保证框架中使用 EPR 剂量测定法比较丙氨酸颗粒

摘要 在过去十年中，丙氨酸/电子顺磁共振 (EPR) 系统的使用扩展到放射治疗剂量。在立体定向放射外科手术中，可将高达 70 Gy 的剂量输送到保留健康组织的脑肿瘤。这种类型的治疗是使用专用设备进行的，如射波刀或伽玛刀。丙氨酸剂量计的特点是体积小（直径 5 毫米）和与组织相似。它们非常适合这种宽剂量范围，在这种范围内，剂量计响应是线性的，在几 MeV 左右的范围内与剂量率和能量无关。因此，丙氨酸/EPR 系统是用于精确和稳定剂量测量的合适方法，作为用于窄治疗光束的被动剂量计，这使其成为使用伽玛刀进行放射外科治疗端到端测试的绝佳候选者。目前的工作描述了罗马尼亚 Horia Hulubei 国家物理与核工程研究所 (IFIN-HH) 的丙氨酸/EPR 方法的发展，包括优化 IFIN-HH 框架内放射外科剂量范围的系统参数和法国国家计量研究所由法国国家计量与论文实验室 (LNE-LNHB) 联合成立的法国国家亨利贝克勒尔实验室（Laboratoire National Henri Becquerel）。通过比较两个国家实验室使用 Bruker 和 Synergy Health 丙氨酸颗粒的校准曲线，展示了罗马尼亚的丙氨酸剂量测量能力。