A stereodivergent approach to 2-alkynyl buta-1,3-dienes from a single stereoisomer of starting α-bromoenal has been developed. By simply switching the sequence of Sonogashira and Horner-Wadsworth-Emmons reactions, it is possible to obtain these branched dienynes with retention or almost complete inversion of the double bond configuration.

中文翻译：

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使用Sonogashira偶联和可控制的烯烃几何形状保留或反转的立体发散合成2-炔基丁-1,3-二烯

已经开发了从起始α-溴烯醛的单一立体异构体到2-炔基丁-1,3-二烯的立体发散方法。通过简单地切换Sonogashira和Horner-Wadsworth-Emmons反应的顺序，就有可能获得保留或几乎完全反转双键构型的这些支链二烯。