Parkinson's disease is characterized by dopaminergic neuron loss and intracellular inclusions composed mainly of alpha synuclein (α-syn), but the mechanism of pathogenesis is still obscure. In recent years, more attention has been given to the gut as a key player in the initiation and progression of PD pathology. Several studies characterizing changes in the microbiome, particularly the gut microbiome, have been conducted. Although many studies found a decrease in the bacterial family Prevotellaceae and in butyrate-producing bacterial genera such as Roseburia and Faecalibacteria, and an increase in the genera Akkermansia many of the studies reported contradictory findings. In this review, we highlight the findings from the different studies and reflect on the future of microbiome studies in PD research.

中文翻译：

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微生物组变化：帕金森氏病的指标？

帕金森氏病的特点是多巴胺能神经元丢失和主要由α突触核蛋白（α-syn）组成的细胞内包裹体，但其发病机理仍不清楚。近年来，人们越来越重视肠道作为PD病理学起始和进展的关键因素。已经进行了一些表征微生物组特别是肠道微生物组变化的研究。尽管许多研究发现，细菌原核科和产丁酸盐的细菌属（例如玫瑰果属和费氏细菌属）减少，而阿克曼菌属增加，但许多研究都发现了相互矛盾的发现。在这篇综述中，我们重点介绍了不同研究的发现，并回顾了PD研究中微生物组研究的未来。