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NAMI-A preferentially reacts with the Sp1 protein: understanding the anti-metastasis effect of the drug.
Chemical Communications ( IF 4.9 ) Pub Date : 2020-01-08 , DOI: 10.1039/c9cc08775c
Siming Yuan 1 , Siming Chen , Han Wu , Huan Jiang , Shihui Zheng , Qianling Zhang , Yangzhong Liu
Affiliation  

NAMI-A is highly reactive to Sp1, a tumor metastasis related protein, resulting in the perturbation of the protein structure and disruption of the DNA recognition of Sp1. Interestingly, Sp1 is more susceptible than other zinc finger proteins to NAMI-A, suggesting that Sp1 could be the anti-metastasis target of NAMI-A.

中文翻译:

NAMI-A优先与Sp1蛋白反应:了解该药物的抗转移作用。

NAMI-A对Sp1(与肿瘤转移相关的蛋白质)具有高反应性,导致蛋白质结构的扰动和Sp1的DNA识别受到破坏。有趣的是,Sp1比其他锌指蛋白更容易受到NAMI-A的影响,这表明Sp1可能是NAMI-A的抗转移靶标。
更新日期:2020-01-08
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