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Photocatalytic site-selective C-H difluoroalkylation of aromatic aldehydes.
Chemical Communications ( IF 4.9 ) Pub Date : 2020-01-09 , DOI: 10.1039/c9cc09586a
Wei-Ke Tang 1 , Fei Tang , Jun Xu , Qi Zhang , Jian-Jun Dai , Yi-Si Feng , Hua-Jian Xu
Affiliation  

The direct photocatalyzed para-selective CAr-H difluoroalkylation of aromatic aldehyde derivatives has been accomplished using a newly explored catalytic system. In addition, when using para-substituted benzaldehydes as substrates, ortho-selective CAr-H difluoroalkylation was also accomplished. It is worth noting that all the above site-selectivity is opposite to traditional Friedel-Crafts reactions of aromatic aldehydes. The preliminary mechanistic investigations indicate that an electrophilic difluoroalkyl radical is involved in the catalytic cycle.

中文翻译:

芳香族醛的光催化位点选择性CH二氟烷基化。

芳香醛衍生物的直接光催化对位选择性CAr-H二氟烷基化反应已使用新开发的催化系统完成。另外,当使用对位取代的苯甲醛作为底物时,也实现了邻位选择性CAr-H二氟烷基化。值得注意的是,上述所有位点选择性都与传统的芳族醛的Friedel-Crafts反应相反。初步的机械研究表明,亲电子的二氟烷基自由基参与了催化循环。
更新日期:2020-01-09
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