A novel ratiometric surface-enhanced Raman scattering (SERS) biosensor was constructed based on stimuli-responsive DNA functionalized metal organic frameworks (MOFs) for detection of adenosine triphosphate (ATP). As a result, the detection range of ATP was 1 nM to 200 nM with a detection limit of 0.4 nM. The ratiometric SERS biosensor strategy offers a lower detection limit and exhibits a more enhanced performance than the typical SERS detection based on single signal response, which may have potential for detection of other biomolecules or metal ions.

中文翻译：

---

配备DNA结构锁的三磷酸腺苷响应性金属有机骨架，用于构建比例SERS生物传感器。

基于刺激响应的DNA功能化金属有机框架（MOFs）构造了一种新型的比例表面增强拉曼散射（SERS）生物传感器，用于检测三磷酸腺苷（ATP）。结果，ATP的检测范围为1nM至200nM，检测极限为0.4nM。与基于单信号响应的典型SERS检测相比，比例SERS生物传感器策略提供了更低的检测限，并表现出更高的性能，后者可能具有检测其他生物分子或金属离子的潜力。