In the present study, three kinds of functional wound dressings ([email protected], [email protected], and Ag/[email protected]) were developed by template-assisted magnetron sputtering of cotton nonwovens. Scanning electron microscopy and energy dispersive spectrometry revealed a very thin, uniform silver oxides and zinc coating on the cotton cellulose microfibers, which was further confirmed by X-ray diffraction pattern, X-ray photoelectron spectrometry, and thermal gravimetric analysis. The physical characteristics such as high swelling ability, moderate air and water vapor permeabilities, good mechanical properties, and excellent flexibility support the suitability of magnetron sputtering cotton nonwovens for wound dressing applications. Moreover, the Ag/[email protected] showed effective antibacterial activities against Escherichia coli and Staphylococcus aureus, which was mainly attributed to the synergistic effect of electrical stimulation and continuous release of Ag⁺/Zn²⁺. Meanwhile, benefiting from the low metal coating area percentage (17.54%), the Ag/[email protected] exhibited good cytocompatibility. The in vitro and in vivo test show that Ag/[email protected] can remarkably accelerate the wound healing process, which can be attributed to the enhanced cellular migration by electrical stimulation, strong antibacterial activity, good cytocompatibility, and excellent physical properties. Potentially, template-assisted magnetron sputtering may provide a simple, green, and sustainable alternative for the development of functional wound dressings.

中文翻译：

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用于伤口愈合的棉非织造布的模板辅助磁控溅射

在本研究中，通过模板辅助磁控溅射棉非织造布开发了三种功能性伤口敷料（[email protected]、[email protected] 和 Ag/[email protected]）。扫描电子显微镜和能量色散光谱显示棉纤维素微纤维上有一层非常薄、均匀的氧化银和锌涂层，X 射线衍射图、X 射线光电子能谱和热重分析进一步证实了这一点。高溶胀能力、适度的空气和水蒸气渗透性、良好的机械性能和出色的柔韧性等物理特性支持磁控溅射棉无纺布适用于伤口敷料应用。此外，Ag/[email protected] 显示出有效的抗菌活性大肠杆菌和金黄色葡萄球菌，这主要归因于电刺激和Ag ⁺ /Zn ²⁺持续释放的协同作用。同时，得益于较低的金属涂层面积百分比（17.54%），Ag/[email protected] 表现出良好的细胞相容性。体外和体内试验表明，Ag/[email protected] 可以显着加速伤口愈合过程，这可归因于电刺激增强的细胞迁移、较强的抗菌活性、良好的细胞相容性和优异的物理性能。潜在地，模板辅助磁控溅射可以为功能性伤口敷料的开发提供一种简单、绿色和可持续的替代方案。