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Photochemical Flow Synthesis of 3‐Hydroxyazetidines
ChemPhotoChem ( IF 3.7 ) Pub Date : 2019-08-27 , DOI: 10.1002/cptc.201900188
Michele Ruggeri 1 , Amanda W. Dombrowski 2 , Stevan W. Djuric 2 , I. R. Baxendale 1
Affiliation  

A photo‐flow Norrish–Yang cyclisation has been devised that delivers 3‐hydroxyazetidines in good yields. The high reproducibility and short residence times of the flow process enables easy scaling of the transformation allowing access to these valuable chemical entities at synthetically useful multi‐gram scales. A systematic exploration of the constituent structural components was undertaken allowing an understanding of the reactivity and functional group tolerance of the transformation.

中文翻译:

3-羟基氮杂环丁烷的光化学流式合成

已经设计出一种光流动的Norrish-Yang环化反应,该反应可以高产率提供3-羟基氮杂环丁烷。流动过程的高重现性和较短的停留时间使转化变得容易进行规模化,从而可以以合成有用的克级规模获得这些有价值的化学实体。对构成的结构成分进行了系统的探索,以使人们了解转化的反应性和官能团的耐受性。
更新日期:2019-08-27
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