Seven new diterpenoids, including four ent-kaurane-type pierisentkaurans B-E (1-4), one 4,5-seco- ent-kaurane-type pierisentkauran F (5), two leucothane-type 3β,7α,14β-trihydroxy-leucoth-10(20),15-dien-5-one (6) and 10α,16α-dihydroxy-leucoth-5-one (7), along with three known diterpenoids ent-kaurane-type 16α-dihydroxy-6-oxo-ent-kauran-18-oic-acid (8), kalmane-type rhodomollein XXIII (9), and grayanane-type pierisformosoid J (10), were isolated from the roots of Pieris formosa. Their structures with absolute configurations were determined by a series of spectroscopic methods and electronic circular dichroism (ECD) calculations. Compounds 2 and 7 displayed weak analgesic activity at a dose of 5.0 mg/kg (i.p.) compared to the vehicle tests (p < 0.05) in an acetic acid-induced writhing test. At a dose of 0.5 mg/mL, compounds 3 and 7 showed antifeedant activity against Plutella xylostella larvae with inhibition ratios of 27.1% and 52.5%, respectively.

中文翻译：

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来自福寿青菜根的具有不同碳骨架的二萜及其止痛和拒食活性。

七种新的二萜类化合物，包括四个四氢呋喃型pirisentkauran BE（1-4），一个四氢呋喃型十二碳烷piersentkauran F（5），两个白三烷型3β，7α，14β-三羟基亮氨酸-10（20），15-dien-5-one（6）和10α，16α-dihydroxy-leucoth-5-one（7），以及三种已知的二萜类化合物-月桂烷型16α-dihydroxy-6-oxo- ent-kauran-18-oic-acid（8），kalmane型Rhodomollein XXIII（9）和Grayanane型Pierisformosoid J（10）是从Pieris formosa的根中分离出来的。通过一系列光谱方法和电子圆二色性（ECD）计算确定了它们具有绝对构型的结构。与乙酸诱导的扭体试验中的赋形剂试验（p <0.05）相比，化合物2和7在5.0 mg / kg（ip）的剂量下显示出较弱的镇痛活性。在0.5 mg / mL的剂量下，