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Pubertal testosterone correlates with adolescent impatience and dorsal striatal activity.
Developmental Cognitive Neuroscience ( IF 4.7 ) Pub Date : 2019-12-23 , DOI: 10.1016/j.dcn.2019.100749
Corinna Laube 1 , Robert Lorenz 2 , Wouter van den Bos 3
Affiliation  

Recent self-report and behavioral studies have demonstrated that pubertal testosterone is related to an increase in risky and impulsive behavior. Yet, the mechanisms underlying such a relationship are poorly understood. Findings from both human and rodent studies point towards distinct striatal pathways including the ventral and dorsal striatum as key target regions for pubertal hormones. In this study we investigated task-related impatience of boys between 10 and 15 years of age (N = 75), using an intertemporal choice task combined with measures of functional magnetic resonance imaging and hormonal assessment. Increased levels of testosterone were associated with a greater response bias towards choosing the smaller sooner option. Furthermore, our results show that testosterone specifically modulates the dorsal, not ventral, striatal pathway. These results provide novel insights into our understanding of adolescent impulsive and risky behaviors and how pubertal hormones are related to neural processes.



中文翻译:

青春期睾酮与青春期不耐烦和背侧纹状体活动相关。

最近的自我报告和行为研究表明,青春期睾酮与危险和冲动行为的增加有关。然而,人们对这种关系背后的机制知之甚少。人类和啮齿动物研究的结果表明,包括腹侧和背侧纹状体在内的不同纹状体通路是青春期激素的关键目标区域。在这项研究中,我们调查了 10 至 15 岁男孩与任务相关的急躁(N= 75),使用跨期选择任务结合功能磁共振成像和激素评估的措施。睾酮水平升高与选择较小的较早选项的反应偏向较大有关。此外,我们的研究结果表明,睾酮特异性调节背侧而非腹侧纹状体通路。这些结果为我们理解青少年冲动和危险行为以及青春期激素如何与神经过程相关提供了新的见解。

更新日期:2019-12-23
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