The incidence of type 2 diabetes mellitus is increasing worldwide, and it might partly cause metabolic disorder and type 2 diabetes mellitus susceptibility in patients’ offspring through epigenetic modification. However, the underlying mechanisms remain largely unclear. Recent studies have shown a potential link between deoxyribonucleic acid methylation in paternal sperm and susceptibility to type 2 diabetes mellitus in offspring, so this article focuses on whether the whole‐genome methylation profiles of spermatozoa in type 2 diabetes mellitus patients have changed.

中文翻译：

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人类精子的全基因组亚硫酸氢盐测序揭示了来自 2 型糖尿病患者的差异甲基化模式。

2型糖尿病的发病率在全球范围内呈上升趋势，可能通过表观遗传修饰部分导致患者后代代谢紊乱和2型糖尿病易感性。然而，潜在的机制在很大程度上仍不清楚。最近的研究表明父本精子中的脱氧核糖核酸甲基化与后代对 2 型糖尿病的易感性之间存在潜在联系，因此本文重点关注 2 型糖尿病患者精子的全基因组甲基化谱是否发生了变化。