The extracts of S. oleraceus Linn (SOL) and its main phenolic compounds have shown anti-diabetic effects, but their underlying mechanisms for glucose homeostasis remain unclear. The aim of this study is to evaluate the anti-diabetic mechanism of SOL by using the streptozocin (STZ) induced diabetic rat model. When diabetic rats were fed with SOL at a dose of 400 mg/kg/day for 6 weeks, the concentrations of triglycerides (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) were reduced by 43%, 22%, and 16%, respectively. Meanwhile, it was also found that daily feeding of SOL to diabetic rats led to a decrease in plasma glucose level by approximately 23%. Positive effects were observed on glucose homeostasis due to the down-regulation of AMPK/Akt/GSK-3β pathway, as indicated by the suppressions of adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK), protein kinase (Akt) phosphorylation, glycogen synthase kinase 3 beta (GSK-3β), and the hepatic insulin resistance. In HepG2 cells, AMPK, Akt and GSK-3β showed a consistent transcript regulation. SOL at dose of 400 mg/kg/day feeding for 6 weeks showed a positive effect comparable to metformin.

中文翻译：

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樟脑提取物通过AMPK / Akt /GSK-3β信号通路在糖尿病肝脏和HepG2细胞培养物中增强了葡萄糖稳态。

苦竹（S. oleraceus Linn）及其主要酚类化合物的提取物具有抗糖尿病作用，但其葡萄糖稳态的潜在机制尚不清楚。这项研究的目的是通过使用链脲佐星（STZ）诱导的糖尿病大鼠模型评估SOL的抗糖尿病机制。当糖尿病大鼠以400 mg / kg /天的剂量喂食SOL达6周时，甘油三酸酯（TG），总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）的浓度降低了43分别为％，22％和16％。同时，还发现每天向糖尿病大鼠喂食SOL可使血浆葡萄糖水平降低约23％。腺苷5'的抑制表明，由于AMPK / Akt /GSK-3β通路的下调，对葡萄糖稳态具有积极作用。-单磷酸（AMP）激活的蛋白激酶（AMPK），蛋白激酶（Akt）磷酸化，糖原合酶激酶3 beta（GSK-3β）和肝胰岛素抵抗。在HepG2细胞中，AMPK，Akt和GSK-3β表现出一致的转录调控。以400 mg / kg / day的剂量喂食SOL，连续6周显示出与二甲双胍相当的积极作用。