Timely diagnosis of acute myocardial infarction (AMI) strongly impacts the survival rate of patients. The authors report the development of a two-shell hollow silica contrast agent useful for ultrasound (US) imaging, which is able to provide ultra-early diagnosis of AMI. To target the characterization of fast blood flow and high blood pressure in the heart, two shells of hollow silica are adopted with opposite polarities, which assemble based on amino and perfluorodecyl silanes. The external amino silane facilitates the attachment of disease-targeted groups, while the internal perfluorodecyl silane provides great US imaging contrast. The material also possesses superior water dispersity, controllable morphology, low toxicity, and biodegradability both in vitro and in vivo, thus promoting its applications in the ultra-early diagnosis of AMI in rats, and is particularly useful for delineation of myocardial necrosis sites.

中文翻译：

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中空双层硅胶纳米球的超声成像对大鼠急性心肌梗死的早期诊断。

及时诊断急性心肌梗塞（AMI）强烈影响患者的存活率。作者报告了可用于超声（US）成像的两壳中空二氧化硅造影剂的开发，该造影剂能够提供AMI的超早期诊断。为了针对心脏中快速血流和高血压的特征，采用了两个极性相反的空心二氧化硅壳，它们是基于氨基和全氟癸基硅烷组装而成的。外部氨基硅烷可促进疾病靶向基团的连接，而内部全氟癸基硅烷可提供出色的US成像对比度。该材料还具有优异的水分散性，可控的形态，低毒性以及在体内和体外的生物降解性，从而促进了其在大鼠AMI的超早期诊断中的应用，