当前位置: X-MOL 学术Angew. Chem. Int. Ed. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
A Supramolecular-Based Dual-Wavelength Phototherapeutic Agent with Broad-Spectrum Antimicrobial Activity Against Drug-Resistant Bacteria.
Angewandte Chemie International Edition ( IF 16.6 ) Pub Date : 2020-01-23 , DOI: 10.1002/anie.201913506
Zhi-Hao Yu 1 , Xingshu Li 2 , Fugui Xu 3 , Xi-Le Hu 1 , Jiatao Yan 4 , Nahyun Kwon 2 , Guo-Rong Chen 1 , Tingting Tang 5 , Xiaojing Dong 6 , Yiyong Mai 3 , Daijie Chen 6, 7 , Juyoung Yoon 2 , Xiao-Peng He 1 , He Tian 1
Affiliation  

With the ever-increasing threat posed by the multi-drug resistance of bacteria, the development of non-antibiotic agents for the broad-spectrum eradication of clinically prevalent superbugs remains a global challenge. Here, we demonstrate the simple supramolecular self-assembly of structurally defined graphene nanoribbons (GNRs) with a cationic porphyrin (Pp4N) to afford unique one-dimensional wire-like GNR superstructures coated with Pp4N nanoparticles. This Pp4N/GNR nanocomposite displays excellent dual-modal properties with significant reactive-oxygen-species (ROS) production (in photodynamic therapy) and temperature elevation (in photothermal therapy) upon light irradiation at 660 and 808 nm, respectively. This combined approach proved synergistic, providing an impressive antimicrobial effect that led to the complete annihilation of a wide spectrum of Gram-positive, Gram-negative, and drug-resistant bacteria both in vitro and in vivo. The study also unveils the promise of GNRs as a new platform to develop dual-modal antimicrobial agents that are able to overcome antibiotic resistance.

中文翻译:

一种基于超分子的双波长光疗剂,具有抗耐药细菌的广谱抗菌活性。

随着细菌对多种药物的耐药性所构成的威胁日益增加,开发用于广泛消灭临床上普遍存在的超级细菌的非抗生素药物仍然是全球性挑战。在这里,我们演示了结构简单的超分子自组装结构定义的石墨烯纳米带(GNRs)与阳离子卟啉(Pp4N),从而提供了涂覆有Pp4N纳米粒子的独特的一维线状GNR超结构。这种Pp4N / GNR纳米复合材料显示出优异的双峰性质,分别在660和808 nm的光照射下具有显着的活性氧(ROS)产生(在光动力疗法中)和温度升高(在光热疗法中)。这种结合的方法被证明具有协同作用,提供令人印象深刻的抗菌效果,从而在体外和体内彻底消灭了广泛的革兰氏阳性,革兰氏阴性和耐药菌。该研究还揭示了GNRs作为开发能够克服抗生素耐药性的双峰抗菌剂的新平台的希望。
更新日期:2020-01-23
down
wechat
bug