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Insights into Oxidation of the Ultrahigh Molecular Weight Polyethylene Artificial Joint Related to Lipid Peroxidation
ACS Applied Bio Materials ( IF 4.7 ) Pub Date : 2020-01-06 , DOI: 10.1021/acsabm.9b00960
Yue Ren 1 , Zi-Yang Wang 1 , Xin Wei 1 , Lu Xu 2 , Rizwan M Gul 3 , Shi-Shu Huang 4 , Jia-Zhuang Xu 1 , Zhong-Ming Li 1
Affiliation  

Oxidative degradation of ultrahigh molecular weight polyethylene (UHMWPE) bearings is one of the main factors that deteriorates their mechanical properties and abrasive wear resistance, which further results in the failure of total joint replacements. Absorption and diffusion of synovial fluids have been considered as causes of the oxidation of UHMWPE bearings. However, the role of synovial fluids in oxidation of UHMWPE remains elusive. In this work, we aimed to reveal the oxidation mechanism of UHMWPE joints with respect to squalene (a representative component of the synovial fluid). The UHMWPE doped in squalene showed slight oxidation, while severe oxidation was observed when squalene doped UHMWPE was exposed to oxygen atmosphere. Squalene manifested lipid peroxidation with notable oxidation products and oxygen-derived free radicals during thermo-oxidative aging. Lipid peroxidation was deduced to follow two routes including autoxidation and thermal oxidation. The aggressive free radicals of squalene abstracted hydrogen atoms from the UHMWPE chains, initiating the oxidation of UHMWPE artificial joints. These findings not only provide evidence for comprehending the process of squalene-induced UHMWPE oxidation but also are instructive to develop highly oxidative-resistant UHMWPE.

中文翻译:

脂质过氧化相关的超高分子量聚乙烯人工关节氧化研究

超高分子量聚乙烯(UHMWPE)轴承的氧化降解是其机械性能和耐磨性劣化的主要因素之一,进一步导致全关节置换失败。滑液的吸收和扩散被认为是 UHMWPE 轴承氧化的原因。然而,滑液在 UHMWPE 氧化中的作用仍然难以捉摸。在这项工作中,我们旨在揭示 UHMWPE 关节相对于角鲨烯(滑液的代表性成分)的氧化机制。掺入角鲨烯的UHMWPE表现出轻微的氧化,而当掺入角鲨烯的UHMWPE暴露于氧气气氛时,则观察到严重的氧化。角鲨烯在热氧化老化过程中表现出脂质过氧化,具有显着的氧化产物和氧衍生自由基。脂质过氧化被推断遵循两条路线,包括自氧化和热氧化。角鲨烯的激进自由基从 UHMWPE 链中提取氢原子,引发 UHMWPE 人工关节的氧化。这些发现不仅为理解角鲨烯诱导的超高分子量聚乙烯氧化过程提供了证据,而且对开发高度抗氧化的超高分子量聚乙烯具有指导意义。
更新日期:2020-01-07
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