Abstract Poly(amide-imide)s (PAIs) present limited use in bioapplications due to their poor aqueous solubility and difficulty in functional accessibility. Herein, we prepared PAI-based prodrugs by leveraging aliphatic PAIs as the polymer scaffolds and conjugating camptothecin (CPT) via thiol-disulfide exchange reaction. The degree of CPT attachment can be smoothly controlled by initial feed ratios of PEG and a pyridinedisulfide-modified CPT precursor. Due to the abundant secondary amine groups in PAI backbones, amphiphilic PAI-CPT prodrugs self-assembled into cationic nanoparticles and showed an efficient cellular internalization (

中文翻译：

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具有可变纳米形态的阳离子聚（酰胺-酰亚胺）-共轭喜树碱前药，用于有效的还原反应药物递送

摘要 聚（酰胺-酰亚胺）（PAI）由于水溶性差和功能可及性困难，在生物应用中的应用有限。在此，我们通过利用脂肪族 PAI 作为聚合物支架并通过硫醇-二硫化物交换反应结合喜树碱 (CPT) 来制备基于 PAI 的前药。CPT 的附着程度可以通过 PEG 和吡啶二硫化物修饰的 CPT 前体的初始进料比来平稳控制。由于 PAI 主链中丰富的仲胺基团，两亲性 PAI-CPT 前药自组装成阳离子纳米颗粒并显示出有效的细胞内化。