Monitoring the activity of systemic lupus erythematosus (SLE) is important to patient management. Blood biochemical indexes are commonly assessed but are both time demanding and traumatizing. In this study, a noninvasive and real‐time spatial‐spectral data tool was used to monitor SLE patients through rash spectral data. To build the relationship between the rash spectrum changes and changes in the patients' status, a snapshot hyperspectral Fourier transform imaging spectrometer was built to monitor the rash reflectance changes of hospitalized SLE patients. A simple rash activity index (RAI) which was normally distributed with the doctor's visual rating of rash severity was calculated from hyperspectral images. The sensitivity of the change in RAI is higher than complement 3/4 levels. RAI and anti‐dsDNA antibodies both decreased as the patients recovered. Anti‐dsDNA and complement 3/4 were important indicators of SLE activity suggesting that the RAI directly correlated with patient status. The snapshot spectrometer therefore provides an auxiliary method to monitor SLE disease.

中文翻译：

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使用快照光谱成像对由系统性红斑狼疮疾病引起的皮疹进行体内监测。

监测系统性红斑狼疮（SLE）的活动对患者管理很重要。血液生化指标通常得到评估，但既耗时又令人痛苦。在这项研究中，非侵入性和实时的空间光谱数据工具用于通过皮疹光谱数据监测SLE患者。为了建立皮疹光谱变化与患者状况变化之间的关系，建立了快照高光谱傅里叶变换成像光谱仪来监测住院SLE患者的皮疹反射率变化。从高光谱图像中计算出一个简单的皮疹活动指数（RAI），该指数通常随医生对皮疹严重程度的视觉评估而分布。RAI变化的敏感性高于补体3/4水平。随着患者的康复，RAI和抗dsDNA抗体均下降。抗dsDNA和补体3/4是SLE活性的重要指标，表明RAI与患者状态直接相关。因此，快照光谱仪提供了一种监测SLE疾病的辅助方法。