Abstract Estrogens are currently considered the most prescribed drugs in the world. These contaminants are not entirely metabolized by humans and therefore, they have been detected in different effluents. Several studies already demonstrated that the hormones are classified as the major responsible for causing endocrine changes in living organisms. In this context, this work aims the selective extraction of hormones based on aqueous two-phase systems (ATPS) composed of acetonitrile (ACN) + double protic ionic liquids (PILs) + water. The respective ATPS pseudo-ternary phase diagrams, were determined at 298.15 ± 1.00 K and 0.10 ± 0.01 MPa. Thereby, their performance as extraction strategies was evaluated using four hormones (Progesterone, 17β-estradiol, estriol and 17α-ethinylestradiol). The binodal curve follows the order of PILs hydrophobicity, exhibiting intermediate biphasic region size between systems using the single PILs. The systems were able to extract selectively two hormones for each phase. Progesterone (PROG) and 17β-estradiol (E2) preferentially migrated to the ACN-rich phase (K > 1), while estriol (E3) 17α-ethinylestradiol (EE2) has higher affinity for the PIL-rich phase (K

中文翻译：

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双质子离子液体+乙腈水性两相体系选择性提取雌性激素

摘要 雌激素目前被认为是世界上处方最多的药物。这些污染物不会完全被人类代谢，因此，它们已在不同的污水中被检测到。几项研究已经表明，激素被归类为导致生物体内分泌变化的主要因素。在此背景下，这项工作旨在基于由乙腈 (ACN) + 双质子离子液体 (PIL) + 水组成的水性两相系统 (ATPS) 选择性提取激素。各自的 ATPS 伪三元相图在 298.15 ± 1.00 K 和 0.10 ± 0.01 MPa 下确定。因此，使用四种激素（孕酮、17β-雌二醇、雌三醇和 17α-炔雌醇）评估了它们作为提取策略的性能。双节点曲线遵循 PILs 疏水性的顺序，在使用单个 PIL 的系统之间表现出中间双相区域大小。该系统能够为每个阶段选择性地提取两种激素。孕酮 (PROG) 和 17β-雌二醇 (E2) 优先迁移到富含 ACN 的相 (K > 1)，而雌三醇 (E3) 17α-炔雌醇 (EE2) 对富含 PIL 的相 (K