Quinolones and isoquinolones are of interest to pharmaceutical industry owing to their potent biological activities. Herein, we first encapsulated sub-nm Pt nanoclusters into Zr-porphyrin frameworks to afford an efficient photocatalyst Pt_0.9@PCN-221. This catalyst can dramatically promote electron-hole separation and ¹O₂ generation to achieve synergistic effect first in the metal-organic framework (MOF) system, leading to the highest activity in photosynthesis of (iso)quinolones in >90.0% yields without any electronic sacrificial agents. Impressively, Pt_0.9@PCN-221 was reused 10 times without loss of activity and can catalyze gram-scale synthesis of 1-methyl-5-nitroisoquinolinone at an activity of 175.8 g·g_cat⁻¹, 22 times higher than that of PCN-221. Systematic investigations reveal the contribution of synergistic effect of photogenerated electron, photogenerated hole, and ¹O₂ generation for efficient photo-oxidation, thus highlighting a new strategy to integrate multiple functional components into MOFs to synergistically catalyze complex photoreactions for exploring biologically active heterocyclic molecules.

喹诺酮和异喹诺酮由于其强大的生物活性而引起制药业的兴趣。在这里，我们首先将亚纳米Pt纳米簇封装到Zr-卟啉骨架中，以提供有效的光催化剂Pt _0.9 @ PCN-221。该催化剂可显着促进电子-空穴的分离和¹ O _2的产生，从而首先在金属有机骨架（MOF）系统中实现协同作用，从而导致（异）喹诺酮在光合作用中的最高活性，产率> 90.0％，而无需任何电子牺牲剂。令人印象深刻的是，Pt _0.9 @ PCN-221在没有活性损失的情况下可重复使用10次，并且可以催化克级规模的15.8克·克_猫的1-甲基-5-硝基异喹啉酮的合成。^-1，比PCN-221高22倍。系统研究揭示了光生电子，光生空穴和¹ O ₂生成对有效光氧化的协同作用，从而突出了一种将多种功能组分整合到MOF中以协同催化复杂光反应以探索生物活性杂环分子的新策略。