microRNAs are small, noncoding RNA that negatively regulate gene expression. Since their discovery in 1993, approximately 2500 human mature microRNAs have been discovered and details of their biogenesis, mechanism of action, and function has been studied. Aberrant expression of microRNAs has since been observed in numerous disease states particularly cancer, neurologic disorders, autoimmune diseases, metabolic diseases and cardiovascular diseases. Because of this, a strong interest in developing novel therapies that modulate microRNA function has emerged. Although, several strategies have been employed, small molecule drugs have shown great promise due their inherent stability, bioavailability, and cost-efficiency. In this review, we discuss the microRNA modulating small molecules that have thus far been identified in the literature and highlight the need for continued research in this field.

中文翻译：

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目前鉴定的microRNA功能的小分子调节剂的综述。

microRNA是小的非编码RNA，会对基因表达产生负面影响。自从1993年被发现以来，已经发现了大约2500种人类成熟的microRNA，并且已经对其生物发生，作用机制和功能进行了详细研究。从那以后，已经在许多疾病状态，尤其是癌症，神经系统疾病，自身免疫疾病，代谢疾病和心血管疾病中观察到了微小RNA的异常表达。因此，人们对开发可调节microRNA功能的新型疗法产生了浓厚的兴趣。尽管已经采用了几种策略，但是小分子药物由于其固有的稳定性，生物利用度和成本效率而显示出了巨大的希望。在这篇评论中，