Microbially derived peptides that mimic immunogenic gliadin peptides in celiac disease have been identified using a structure- and sequence-guided search. T cell activation assays and crystal structures reveal that a protein from the commensal bacterium Pseudomonas fluorescens can be processed and presented by antigen-presenting cells to potently activate T cells from patients with celiac disease.

中文翻译：

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肠道内的敌人：腹腔自身免疫中的细菌性病原体。

已使用结构和序列指导的搜索方法鉴定了在乳糜泻中模拟免疫原性麦醇溶蛋白肽的微生物衍生肽。T细胞活化试验和晶体结构表明，共生细菌荧光假单胞菌的蛋白质可以被抗原呈递细胞加工并呈递，从而有效活化腹腔疾病患者的T细胞。