Mechanochemical approaches in an organic synthesis have received increased interest because of their wide applications in green methodologies. Ball milling has been fruitfully utilized in the synthesis of various (elemental) organic scaffolds, including common drugs or drug candidates. However, the utilization of ball milling in asymmetric organic synthesis has not been adequately investigated. Thus, the aim of this review is to highlight the attractive features of the applications of mechanochemistry via ball milling in asymmetric organic syntheses in order to attract the attention of a wider section of the synthesis community.

中文翻译：

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球磨：一种不对称有机合成的高效绿色方法

由于有机化学中的机械化学方法在绿色方法学中的广泛应用，因此受到了越来越多的关注。球磨已被有效地用于各种（元素）有机支架的合成，包括普通药物或候选药物。然而，尚未充分研究球磨在不对称有机合成中的利用。因此，本综述的目的是突出通过不对称有机合成中的球磨进行机械化学应用的吸引人的特征，以吸引合成界的广泛关注。