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Cobaltaelectro-catalyzed oxidative allene annulation by electro-removable hydrazides.
Chemical Communications ( IF 4.9 ) Pub Date : 2020-01-08 , DOI: 10.1039/c9cc09076b
Ruhuai Mei 1 , Xinyue Fang 2 , Liang He 3 , Junmei Sun 3 , Liang Zou 4 , Wenbo Ma 2 , Lutz Ackermann 5
Affiliation  

An efficient C-H/N-H functionalization with allenes was enabled via versatile electro-oxidative cobalt catalysis. Thus, electrochemical C-H activations were accomplished with high levels of chemoselectivity and regioselectivity in an operationally simple undivided cell setup. The user-friendly nature of this protocol was highlighted by excellent functional group tolerance, an electro-reductive removable hydrazide directing group and easy scalability. Experimental mechanistic studies were indicative of a facile BIES C-H cobaltation event.

中文翻译:

通过可电去除的酰肼进行钴电催化的氧化异戊烯环化反应。

通过多用途的电氧化钴催化,可以实现用烯丙烯进行有效的CH / NH官能化。因此,在操作简单的未分裂细胞设置中,以高水平的化学选择性和区域选择性实现了电化学CH活化。该协议具有用户友好的特性,它具有出色的官能团耐受性,可电还原的可移动酰肼导向基团和易于扩展的特性。实验机理研究表明,BIES CH钴化反应较容易。
更新日期:2020-01-08
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