The goal was to characterize the clinical-epidemiological profile of patients with mucocutaneous tumoural herpes simplex virus (MCT HSV) lesions across the world. Two researchers extracted and independently reviewed data from the literature search engine PubMed/MEDLINE through October 2018. From 110 reported patients, the following data were available: the patients' ages ranged from 7 to 76 years; the majority was male (62.73 %-69/110) and immunosuppression was found in 97.25 % (106/109, missing 1) cases, of whom 88 were HIV- related. Lesions size varied from 0.2-13 cm, settling in the anogenital region in 76.36 % (84/110) patients; 84.13 % (53/63, missing 47) complained of pain and multiple recurrences were found in 44.94 % (40/89, missing 21) cases. On clinical basis, the initial hypothesis was neoplasia in 36/53 patients. Histopathological diagnosis was achieved in 90 % (90/100, missing 10) cases and was sample size-dependent. Type 2 HSV was detected in 86.07 % (68/79, missing 31) lesions. MCT HSV lesions recurrence after treatment was reported in 33.96 % (18/53, missing 57) patients. Pathophysiology is poorly understood. Physicians should be aware of MCT HSV lesions in immunosuppressed patients to avoid inappropriate therapeutic strategies.

中文翻译：

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单纯疱疹病毒粘膜皮肤肿瘤病变-系统评价。

目的是表征全世界粘膜皮肤单纯疱疹病毒（MCT HSV）病变患者的临床流行病学特征。截至2018年10月，两名研究人员从文献搜索引擎PubMed / MEDLINE中提取并独立审查了数据。从110位报告的患者中可获得以下数据：患者年龄在7至76岁之间；多数为男性（62.73％-69 / 110），在97.25％（106/109，缺失1）的病例中发现了免疫抑制，其中88例与HIV相关。病变大小在0.2-13厘米之间变化，在76.36％（84/110）的患者中位于肛门生殖器区域。84.13％（53/63，失踪47）抱怨疼痛，在44.94％（40/89，失踪21）病例中发现多次复发。在临床基础上，最初的假设是36/53例患者的肿瘤形成。90％（90/100，遗失10）例病例均获得了组织病理学诊断，并且与样本量有关。在86.07％（68/79，缺失31）病变中检测到2型HSV。据报告，治疗后MCT HSV病变复发率为33.96％（18/53，缺失57位）。病理生理学知之甚少。医师应注意免疫抑制患者的MCT HSV病变，以避免不合适的治疗策略。