During development, disease or in response to changes in local environmental and/or nutrient supply, cellular metabolism is substantially remodeled. Reduced mitochondrial Ca2+ uptake was recently reported to induce metabolic remodeling, which through stimulating alterations in the epigenome causes changes in gene expression associated with fibroblast to myofibroblast differentiation.

中文翻译：

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线粒体Ca2 + LaMety指导纤维化。

在发育过程中，疾病或对局部环境和/或营养供应的变化做出反应时，细胞代谢会发生实质性的重塑。最近有报道说，线粒体对Ca2 +的吸收减少会引起代谢重塑，这通过刺激表观基因组的改变而引起与成纤维细胞向成肌纤维细胞分化相关的基因表达变化。