BACKGROUND Various types of medical glues/adhesives/topical coagulants' (referred to as MG hereinafter) have widespread application as surgical adhesives, and have been shown to be safe and effective for a broad range of usage, such as in hemostasis, reinforcement of intestinal anastomoses or sites of potential fluid leakage, adhesion of two surfaces, wound closure, and vascular embolization. However, inappropriate application of MG may sometimes lead to serious complications. Herein, we describe three cases of serious postoperative complications induced by a possible inappropriate use of N-butyl-2-cyanoacrylate MG (NBCA MG). CASE PRESENTATION Three patients presented with abdominal pain (chronic pain in cases 1 and 2, and acute pain in Case 3), hematochezia (Case 2), and intestinal obstruction (Case 3). All patients had a history of abdominal surgery and intraoperative use of NBCA MG. Abdominal computed tomography and gastroenterological endoscopy revealed foreign bodies (solidified MG in cases 1 and 2) and intestinal obstruction related to a mass of residual non-absorbed MG causing an internal hernia from a dense adhesion (Case 3). All patients underwent exploratory laparotomy, which revealed duodenal perforation, colonic erosion, and an internal hernia, all of which was related to MG use. We undertook removal of the foreign bodies (cases 1 and 2), surgical closure of the site of duodenal erosion (Case 1), partial colectomy (Case 2), and partial enterectomy (Case 3). CONCLUSION Inappropriate application of MG may induce serious complications. We emphasize the importance of careful evaluation of the indications, dosage, and spraying thickness of MG in clinical practice. Serious complications caused by inappropriate application of MG should be reported to raise awareness in the surgical fraternity.

中文翻译：

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医用胶水引起的严重术后并发症：三例。

背景技术各种类型的医用胶/粘合剂/局部凝结剂（以下称为MG）已经广泛地用作外科手术粘合剂，并且已被证明对于止血，增强肠的广泛使用是安全有效的。吻合口或潜在的液体渗漏，两个表面的附着，伤口闭合和血管栓塞的部位。但是，不适当使用MG有时可能会导致严重的并发症。在本文中，我们描述了三例由于不适当使用N-丁基-2-氰基丙烯酸酯MG（NBCA MG）引起的严重术后并发症的情况。病例介绍3例患者出现腹痛（病例1和2为慢性疼痛，病例3为急性疼痛），便血（病例2）和肠梗阻（病例3）。所有患者都有腹部手术史，术中使用NBCA MG。腹部计算机断层扫描和肠胃镜检查发现异物（病例1和2中的MG固结）和肠梗阻与大量未吸收的MG有关，致密疝致内疝（病例3）。所有患者均接受了探查性剖腹手术，这些手术显示出十二指肠穿孔，结肠糜烂和内部疝气，所有这些均与MG的使用有关。我们进行了异物清除（病例1和2），手术关闭十二指肠糜烂部位（病例1），部分结肠切除术（病例2）和部分肠切除术（病例3）。结论MG的不当使用可能会导致严重的并发症。我们强调仔细评估适应症，剂量，临床实践中MG的喷涂厚度。应报告由于不适当使用MG引起的严重并发症，以提高对手术友爱的认识。