Tertiary amines are poor directing groups for C(sp3)–H activation using Pdii catalysts due to favourable β-hydride elimination pathways. Now, an N-acetyl amino acid ligand is shown to shut down this deleterious pathway, enabling facile arylation of a highly medicinally relevant group of compounds.

中文翻译：

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教一个旧的配体新技巧。

由于有利的β-氢化物消除途径，叔胺对于使用Pdii催化剂进行C（sp3）–H活化作用的指导基团较差。现在，N-乙酰基氨基酸配体被证明可以关闭这种有害的途径，从而使与药物高度相关的一组化合物易于芳基化。