To take full advantage of the drug delivery benefits offered by bilayer tablets, the common issue of weak interfacial bonding strength (IBS) with manufacturing must be overcome. This work seeks to characterize the effects of composition in individual layers and compaction pressure on the IBS. Mixtures of MCC and lactose in different ratios with and without HPMC were used where the first layer was compacted with two different pressures (20 and 100 MPa) followed by a second layer compaction pressure of 200 MPa. After identifying the failure mode as either at the interface or within a layer, the complex trends of bilayer tablet IBS as a function of MCC content were explained by considering the interplay between particle bonding strength and bonding area at the interface.

中文翻译：

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配制的双层片剂中的界面键合。

为了充分利用双层片剂提供的药物传递优势，必须克服制造过程中界面粘结强度（IBS）较弱的普遍问题。这项工作旨在表征IBS中各层组成和压实压力的影响。使用具有和不具有HPMC的MCC和乳糖的不同比例的混合物，其中第一层用两个不同的压力（20和100 MPa）压实，然后第二层压实压力为200 MPa。在确定了故障模式是在界面还是在层内之后，通过考虑颗粒结合强度和界面结合面积之间的相互作用，解释了双层片剂IBS作为MCC含量的函数的复杂趋势。