Although the role of immune dysregulation in hidradenitis suppurativa (HS) has yet to be elucidated, recent studies identified several complement abnormalities in patients with HS. The complement system serves a critical role in the modulation of immune response and regulation of cutaneous commensal bacteria. Complement is implicated in several inflammatory skin diseases including systemic lupus erythematosus, angioedema, pemphigus, bullous pemphigoid, and HS. A model of HS pathogenesis is proposed, integrating the role of commensal bacteria, cutaneous immune responses, and complement dysregulation. The role of complement in disease pathogenesis has led to the development of novel anticomplement agents and clinical trials investigating the efficacy of such treatments in HS.

中文翻译：

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补体途径在炎性皮肤疾病中的作用：以化脓性汗腺炎为重点。

尽管尚不清楚免疫异常调节在化脓性汗腺炎（HS）中的作用，但最近的研究发现了HS患者的几种补体异常。补体系统在调节免疫应答和调节皮肤共生细菌中起关键作用。补体与几种炎性皮肤疾病有关，包括系统性红斑狼疮，血管性水肿，天疱疮，大疱性天疱疮和HS。提出了HS发病机制的模型，该模型整合了共生细菌，皮肤免疫反应和补体调节异常的作用。补体在疾病发病机理中的作用导致了新型抗补体剂的开发，并研究了此类疗法在HS中的疗效的临床试验。