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Myricitrin exhibits anti-atherosclerotic and anti-hyperlipidemic effects in diet-induced hypercholesterolemic rats.
AMB Express ( IF 3.7 ) Pub Date : 2019-12-21 , DOI: 10.1186/s13568-019-0924-0
Jing Gao 1 , Cuicui Liu 2 , Heping Zhang 1 , Zhen Sun 1 , Rongmei Wang 1
Affiliation  

The present study investigated the anti-atherosclerotic potential of myricitrin in hypercholesterolemic rats. Rats were divided into the following groups: sham (standard food), control [1% high-cholesterol diet (HCD)], 1 μM myricitrin + 1% HCD, 10 μM myricitrin + 1% HCD, 100 μM myricitrin + 1% HCD, and the positive control (10 mg/kg body weight atorvastatin). The dose was given to rats via oral gavage for 45 consecutive days. Feeding of rats with 1% HCD caused substantial increases in the levels of LDL, cholesterol, and triglycerides (TG), while high-density lipoprotein (HDL) was reduced. However, rats supplemented with myricitrin had reduced levels of cholesterol, LDL, and TG to near-normal levels, whereas HDL was increased. Catalase, superoxide dismutase (SOD), glutathione peroxidase (Gpx), and reduced glutathione (GSH) levels were substantially reduced in the HCD-fed rats compared with sham rats. However, the rats supplemented with 100 μM myricitrin showed > 50% increases in these levels. Lipid peroxidation and reactive oxygen species (ROS) levels were reduced following myricitrin treatment. The aortic cell wall area was significantly increased by 14.5% in HCD-fed rats. However, rats supplemented with 1, 10, and 100 μM myricitrin showed significant reductions in the aortic cell wall area of 2.3%, 4%, and 27.5%, respectively. This is the first report of the anti-atherosclerotic and hypolipidemic effects of myricitrin in hypercholesterolemic rats. Myricitrin decreased the level of total serum cholesterol and the role of aortic atherosclerosis in hypercholesterolemic rats.

中文翻译:

杨梅素在饮食诱导的高胆固醇血症大鼠中表现出抗动脉粥样硬化和抗高血脂的作用。

本研究调查了高胆固醇血症大鼠体内杨梅苷的抗动脉粥样硬化潜力。大鼠分为以下几组:假(标准食品),对照组[1%高胆固醇饮食(HCD)],1μM肉豆蔻素+ 1%HCD,10μM肉豆蔻素+ 1%HCD,100μM肉豆蔻素+ 1%HCD ,以及阳性对照(体重为10 mg / kg的阿托伐他汀)。连续45天通过口服管饲法给大鼠剂量。用1%的HCD喂养大鼠会导致LDL,胆固醇和甘油三酸酯(TG)的水平大量增加,而高密度脂蛋白(HDL)则降低。但是,补充了杨梅素的大鼠胆固醇,LDL和TG的水平降低至接近正常水平,而HDL升高。过氧化氢酶,超氧化物歧化酶(SOD),谷胱甘肽过氧化物酶(Gpx),与假手术大鼠相比,用HCD喂养的大鼠的谷胱甘肽和降低的谷胱甘肽(GSH)水平显着降低。但是,补充有100μM杨梅素的大鼠的这些水平增加了> 50%。肉豆蔻苷处理后,脂质过氧化和活性氧(ROS)含量降低。用HCD喂养的大鼠的主动脉细胞壁面积显着增加了14.5%。但是,补充有1、10和100μM杨桃素的大鼠的主动脉细胞壁面积分别明显减少了2.3%,4%和27.5%。这是肉豆蔻酸在高胆固醇血症大鼠中的抗动脉粥样硬化和降血脂作用的首次报道。杨梅苷降低高胆固醇血症大鼠的总血清胆固醇水平和主动脉粥样硬化的作用。补充了100μM杨梅素的大鼠的这些水平增加了> 50%。肉豆蔻毒素处理后脂质过氧化和活性氧(ROS)含量降低。用HCD喂养的大鼠的主动脉壁面积显着增加了14.5%。但是,补充有1、10和100μM杨桃素的大鼠的主动脉细胞壁面积分别明显减少了2.3%,4%和27.5%。这是肉豆蔻酸在高胆固醇血症大鼠中的抗动脉粥样硬化和降血脂作用的首次报道。杨梅苷降低高胆固醇血症大鼠的总血清胆固醇水平和主动脉粥样硬化的作用。补充了100μM杨梅素的大鼠的这些水平增加了50%以上。肉豆蔻毒素处理后脂质过氧化和活性氧(ROS)含量降低。用HCD喂养的大鼠的主动脉细胞壁面积显着增加了14.5%。但是,补充有1、10和100μM杨桃素的大鼠的主动脉细胞壁面积分别明显减少了2.3%,4%和27.5%。这是肉豆蔻酸在高胆固醇血症大鼠中的抗动脉粥样硬化和降血脂作用的首次报道。杨梅苷降低高胆固醇血症大鼠的总血清胆固醇水平和主动脉粥样硬化的作用。肉豆蔻毒素处理后脂质过氧化和活性氧(ROS)含量降低。用HCD喂养的大鼠的主动脉壁面积显着增加了14.5%。但是,补充有1、10和100μM杨桃素的大鼠的主动脉细胞壁面积分别明显减少了2.3%,4%和27.5%。这是肉豆蔻酸在高胆固醇血症大鼠中的抗动脉粥样硬化和降血脂作用的首次报道。杨梅苷降低高胆固醇血症大鼠的总血清胆固醇水平和主动脉粥样硬化的作用。肉豆蔻苷处理后,脂质过氧化和活性氧(ROS)含量降低。用HCD喂养的大鼠的主动脉细胞壁面积显着增加了14.5%。但是,补充有1、10和100μM杨桃素的大鼠的主动脉细胞壁面积分别明显减少了2.3%,4%和27.5%。这是肉豆蔻酸在高胆固醇血症大鼠中的抗动脉粥样硬化和降血脂作用的首次报道。杨梅苷降低高胆固醇血症大鼠的总血清胆固醇水平和主动脉粥样硬化的作用。这是肉豆蔻酸在高胆固醇血症大鼠中的抗动脉粥样硬化和降血脂作用的首次报道。杨梅苷降低高胆固醇血症大鼠的总血清胆固醇水平和主动脉粥样硬化的作用。这是肉豆蔻酸在高胆固醇血症大鼠中的抗动脉粥样硬化和降血脂作用的首次报道。杨梅苷降低高胆固醇血症大鼠的总血清胆固醇水平和主动脉粥样硬化的作用。
更新日期:2019-12-21
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