BACKGROUND Fibroadenoma is the most prevalent benign breast lesion that generally affects middle-aged women; it is rare in adolescents and younger children. The transformation into malignancy is not common. However, multiple recurrences of rapidly enlarging fibroadenomas suggest a high possibility of transforming into phyllodes tumors, which are uncommon fibroepithelial lesions that account for 0.3-0.5% of female breast tumors and typically present in premenopausal women. CASE PRESENTATION We report a case of a 17-year-old Syrian girl who previously had three episodes of recurrence of multiple rapidly enlarging fibroadenomas in her left breast and underwent three operations for complete resection of the lesions. However, a few months later, she was readmitted with multiple large masses in the same breast, and pathological findings confirmed a surprising combination of multiple fibroadenomas for the fourth time with a malignant phyllodes tumor (cystosarcoma phyllodes). The patient underwent lumpectomies followed by adjuvant radiotherapy. Long-term follow-up was recommended. CONCLUSION Our patient had an extraordinary number of episodes of recurrence at a young age and a rare combination of malignant and benign lesions in the same breast with multiple recurrences. We present her unique, very challenging case with the aim of highlighting the importance of clinical correlation, detailed diagnosis, and careful follow-up.

中文翻译：

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一名17岁女孩复发性巨纤维腺瘤转化为囊状肉囊瘤：叙利亚的一例罕见病例报告。

背景纤维腺瘤是最普遍的乳腺良性病变，通常会影响中年女性。它在青少年和年幼儿童中很少见。转变为恶性肿瘤并不常见。然而，迅速扩大的纤维腺瘤的多次复发提示转化为叶状肿瘤的可能性很高，这是不常见的纤维上皮性病变，占女性乳腺肿瘤的0.3-0.5％，通常存在于绝经前的女性中。病例介绍我们报告了一个17岁的叙利亚女孩的病例，该女孩先前在她的左乳房发生了3次多发迅速扩大的纤维腺瘤的复发，并进行了3次手术以完全切除病灶。但是，几个月后，她再次被同一乳房的多个大肿块再次接纳，病理结果证实了第四次多发性纤维腺瘤与恶性叶状瘤（囊状囊状肉瘤）的惊人结合。患者接受了放射线切开术，随后进行了辅助放疗。建议长期随访。结论我们的患者在年轻时复发的次数非常多，在同一乳腺中恶性和良性病变的罕见合并症是多发性复发。我们介绍她的独特，非常具有挑战性的病例，旨在强调临床相关性，详细诊断和仔细随访的重要性。结论我们的患者在年轻时复发的次数非常多，在同一乳腺中罕见的恶性和良性病变的罕见合并多发性复发。我们介绍她的独特，非常具有挑战性的病例，旨在强调临床相关性，详细诊断和仔细随访的重要性。结论我们的患者在年轻时复发的次数非常多，在同一乳腺中恶性和良性病变的罕见合并症是多发性复发。我们介绍她的独特，非常具有挑战性的病例，旨在强调临床相关性，详细诊断和仔细随访的重要性。