BACKGROUND To study the influencing factors for different healing patterns of patients with idiopathic macular holes (IMH) after vitrectomy surgery performed with the internal limiting membrane (ILM) flap technique. METHODS This study was a retrospective, consecutive, observational case series study. We recruited 52 IMH patients who underwent vitrectomy with the ILM flap technique. The participants were divided into 2 groups: group A (25 patients), without significant glial cell proliferation in the macular area on postoperative optical coherence tomography (OCT); and group B (27 patients), with significant glial cell proliferation. The postoperative visual acuity (VA), external limiting membrane (ELM) and ellipsoid zone (EZ) recovery characteristics were compared between the two groups. RESULTS There were statistically significant differences in minimum linear diameter (MLD) of the macular hole and postoperative VA (p = 0.02, 2.81 E-4 respectively) between the two groups. Compared with patients in group A, patients in group B had poorer VA and EZ recovery in the first 12 months after surgery, and a longer ELM recovery period. The OCT results showed that patients in group B had more extensive ILM filling in the macular area after surgery than patients in group A. CONCLUSION The presence of aberrant glial cell proliferation was related to a larger MLD of the IMH, and the filling approach for the ILM during the operation was related to the postoperative healing pattern and vision acuity.

中文翻译：

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内部限制膜瓣修复特发性黄斑裂孔后神经胶质细胞增殖的危险因素。

背景技术研究采用内限膜（ILM）皮瓣技术进行玻璃体切割手术后特发性黄斑裂孔（IMH）患者不同愈合方式的影响因素。方法本研究是一项回顾性，连续性，观察性病例系列研究。我们招募了52名接受ILM皮瓣技术玻璃体切除术的IMH患者。参加者分为两组：A组（25例），术后光学相干断层扫描（OCT）在黄斑区无明显的胶质细胞增生； A组（25例）。B组（27例患者）具有明显的神经胶质细胞增生。比较两组患者的术后视力（VA），外部限制膜（ELM）和椭球区（EZ）的恢复特征。结果两组之间黄斑裂孔的最小线性直径（MLD）和术后VA差异有统计学意义（分别为p = 0.02、2.81 E-4）。与A组患者相比，B组患者在术后头12个月的VA和EZ恢复较差，ELM恢复期更长。OCT结果表明，与A组相比，B组患者手术后黄斑区的ILM填充更广泛。结论胶质细胞异常增殖的存在与IMH的最大MLD有关，而IMH的填充方法手术中的ILM与术后愈合方式和视力有关。与A组患者相比，B组患者在术后头12个月的VA和EZ恢复较差，ELM恢复期更长。OCT结果表明，与A组相比，B组患者手术后黄斑区的ILM填充更广泛。结论胶质细胞异常增殖的存在与IMH的最大MLD有关，而IMH的填充方法手术中的ILM与术后愈合方式和视力有关。与A组患者相比，B组患者在术后头12个月的VA和EZ恢复较差，ELM恢复期更长。OCT结果表明，与A组相比，B组患者手术后黄斑区的ILM填充更广泛。结论胶质细胞异常增殖的存在与IMH的最大MLD有关，而IMH的填充方法手术中的ILM与术后愈合方式和视力有关。