BACKGROUND Resting heart rate (RHR) is an obtainable, inexpensive, non-invasive test, readily available on any medical document. RHR has been established as a risk factor for cardiovascular morbidity, is related to other cardiovascular risk factors, and may possibly predict them. Change in RHR over time (∆RHR) has been found to be a potential predictor of mortality. METHODS In this prospective study, RHR and ∆RHR were evaluated at baseline and over a period of 2.9 years during routine check-ups in 6683 subjects without known cardiovascular disease from the TAMCIS: Tel-Aviv Medical Center Inflammation Survey. Multiple linear regression analysis with three models was used to examine ∆RHR. The first model accounted for possible confounders by adjusting for age, sex and body mass index (BMI). The 2nd model included smoking status, baseline RHR, diastolic blood pressure (BP), dyslipidemia, high-density lipoprotein (HDL) and metabolic equivalents of task (MET), and in the last model the change in MET and change in BMI were added. RESULTS RHR decreased with age, even after adjustment for sex, BMI and MET. The mean change in RHR was - 1.1 beats/min between two consecutive visits, in both men and women. This ∆RHR was strongly correlated with baseline RHR, age, initial MET, and change occurring in MET and BMI (P < 0.001). CONCLUSIONS Our results highlight the need for examining individual patients' ∆RHR. Reinforcing that a positive ∆RHR is an indicator of poor adherence to a healthy lifestyle.

中文翻译：

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运动能力和体重指数-静息心率变化的重要预测指标。

背景技术静息心率（RHR）是可获得的，廉价的，非侵入性的测试，可容易地在任何医学文献上获得。RHR已被确定为心血管疾病的危险因素，与其他心血管危险因素有关，并且可能会预测它们。已发现RHR随时间的变化（∆RHR）是潜在的死亡率预测指标。方法在这项前瞻性研究中，对TAMCIS：特拉维夫医学中心炎症调查的6683名无已知心血管疾病的受试者进行了基线检查，并在2.9年的定期检查中对RHR和∆RHR进行了评估。使用三个模型的多元线性回归分析来检验∆RHR。第一个模型通过调整年龄，性别和体重指数（BMI）来考虑可能的混杂因素。第二个模型包括吸烟状况，基线RHR，舒张压（BP），血脂异常，高密度脂蛋白（HDL）和任务的代谢当量（MET），并且在最后一个模型中添加了MET的变化和BMI的变化。结果即使调整了性别，BMI和MET，RHR也会随着年龄的增长而下降。男性和女性两次连续访问之间，RHR的平均变化为-1.1次/分钟。该∆RHR与基线RHR，年龄，初始MET以及MET和BMI发生的变化密切相关（P <0.001）。结论我们的结果强调需要检查个别患者的∆RHR。强调ΔRHR为正值表明对健康生活方式的依从性较差。结果即使调整了性别，BMI和MET，RHR也会随着年龄的增长而下降。男性和女性两次连续访问之间，RHR的平均变化为-1.1次/分钟。该∆RHR与基线RHR，年龄，初始MET以及MET和BMI发生的变化密切相关（P <0.001）。结论我们的结果强调需要检查个别患者的∆RHR。强调ΔRHR为正值表明对健康生活方式的依从性较差。结果即使调整了性别，BMI和MET，RHR也会随着年龄的增长而下降。男性和女性两次连续访问之间，RHR的平均变化为-1.1次/分钟。该∆RHR与基线RHR，年龄，初始MET以及MET和BMI发生的变化密切相关（P <0.001）。结论我们的结果强调需要检查个别患者的∆RHR。强调ΔRHR为正值表示对健康生活方式的依从性较差。