Trimethylsilyl trifluoromethanesulfonate (TMSOTf) and a trialkylamine base promote the conversion of acetonitrile to its silyl ketene imine in situ when acetonitrile is employed as solvent. Residual TMSOTf acts as a Lewis acid catalyst to activate acetals and nitrones in the reaction mixture, yielding β-methoxynitriles and β -(silyloxy)aminonitriles, respectively. Some reaction products undergo elimination under the reaction conditions to provide the α, β -unsaturated nitrile directly.

中文翻译：

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乙腈与乙缩醛和硝酮的一锅甲硅烷基乙烯酮亚胺形成亲核加成反应

当使用乙腈作为溶剂时，三氟甲磺酸三甲基甲硅烷基酯（TMSOTf）和三烷基胺碱可促进乙腈原位转化为其甲硅烷基烯酮亚胺。残留的TMSOTf充当路易斯酸催化剂，以活化反应混合物中的乙缩醛和硝酮，分别生成β-甲氧基腈和β-（甲硅烷氧基）氨基腈。一些反应产物在反应条件下被消除，以直接提供α，β-不饱和腈。