Chong-lou, the rhizome of Paris polyphylla, has been used in herbal regimes to treat parotitis, mastitis and certain malignant tumors for thousands of years in traditional medicine. Polyphyllin I (PPI) is the main bioactive component in Paris polyphylla. Recent studies of PPI in various types of cancers have shown that PPI may exert a broad spectrum of anti-tumor effects, including inducing cell cycle arrest, inducing cell apoptosis, inducing autophagy, anti-angiogenesis, sensitizing tumors to chemotherapy, and participating in the modulation of inflammatory and immune response. Along with the growing research interest in PPI as well as accumulation of experimental evidences, this review periodically summarized the recent advances in regard to PPI's anti-tumor propensities in various cancers and the underlying mechanisms for future prospective research.

中文翻译：

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Polyphyllin I的抗癌作用：5年内更新。

重楼是巴黎多叶植物的根茎，在传统医学中已被用于草药治疗腮腺炎，乳腺炎和某些恶性肿瘤，已有数千年的历史了。茶树素I（PPI）是巴黎茶树中的主要生物活性成分。PPI在各种类型的癌症中的最新研究表明，PPI可能发挥广泛的抗肿瘤作用，包括诱导细胞周期停滞，诱导细胞凋亡，诱导自噬，抗血管生成，使肿瘤对化疗敏感以及参与肿瘤的治疗。调节炎症和免疫反应。随着人们对PPI的研究兴趣不断增长，以及实验证据的积累，这篇综述定期总结了有关PPI的最新进展。