Cancer is known as one of the most common diseases that are associated with high mobility and mortality in the world. Despite several efforts, current cancer treatment modalities often are highly toxic and lack efficacy and specificity. However, the application of nanotechnology has led to the development of effective nanosized drug delivery systems which are highly selective for tumors and allow a slow release of active anticancer agents. Different Nanoparticles (NPs) such as the silicon-based nano-materials, polymers, liposomes and metal NPs have been designed to deliver anti-cancer drugs to tumor sites. Among different drug delivery systems, carbohydrate-functionalized nanomaterials, specially based on their multi-valent binding capacities and desirable bio-compatibility, have attracted considerable attention as an excellent candidate for controlled release of therapeutic agents. In addition, these carbohydrate functionalized nano-carriers are more compatible with construction of the intracellular delivery platforms like the carbohydrate-modified metal NPs, quantum dots, and magnetic nano-materials. In this review, we discuss recent research in the field of multifunctional glycol-nanoparticles (GNPs) intended for cancer drug delivery applications.

中文翻译：

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糖纳米颗粒：癌症治疗中的新药物输送系统。

癌症被认为是世界上与高流动性和死亡率相关的最常见疾病之一。尽管做出了一些努力，但目前的癌症治疗方式通常毒性很大，缺乏疗效和特异性。然而，纳米技术的应用导致了有效的纳米级药物递送系统的发展，该系统对肿瘤具有高度选择性，并允许缓慢释放活性抗癌剂。不同的纳米颗粒 (NPs)，如硅基纳米材料、聚合物、脂质体和金属 NPs，已被设计用于将抗癌药物输送到肿瘤部位。在不同的药物递送系统中，碳水化合物功能化的纳米材料，特别是基于它们的多价结合能力和理想的生物相容性，作为控制释放治疗剂的优秀候选者，已经引起了相当大的关注。此外，这些碳水化合物功能化的纳米载体更适合构建细胞内递送平台，如碳水化合物修饰的金属纳米粒子、量子点和磁性纳米材料。在这篇综述中，我们讨论了用于癌症药物递送应用的多功能乙二醇纳米颗粒 (GNP) 领域的最新研究。